Shannon L. Kelleher, Ph.D.

photo of Shannon Kelleher

Associate Professor Nutritional Sciences, Surgery and Cell & Molecular Physiology

Contact Information

H166 Physiology
Hershey Medical Center
Hershey PA 17033

717-531-1778

slk39@psu.edu

nutrition.psu.edu/kelleherlab

Education

Ph.D., Nutrition, University of California, Davis

Research Interests

The role of maternal genetics and diet on mammary gland function and breast health. We focus on understanding the cellular and molecular mechanisms which regulate zinc metabolism in breast cells during lactation and how these mechanisms are dysregulated in breast cancer.

Selected Publications

Kelleher SL, Velasquez V, Croxford T, McCormick NH, Lopez V and MacDavid J. 2011 Mapping the zinc transporting system in mammary cells: Molecular analysis reveals a phenotype-dependent zinc transporting network during lactation. J Cell Physiol, epub.

Seo YA, Lopez V and Kelleher SL. 2011 A histidine-rich motif mediates mitochondrial localization of ZnT2 to modulate mitochondrial function. American Journal of Physiology, Cell Physiology, epub.

Lopez V, Foolad F and Kelleher SL. 2011 ZnT2 attenuation in tumorigenic breast cancer cells results in cell death via caspase-independent apoptosis. Cancer Letters, epub.

McCormick N, Velasquez V, Finney L, Vogt S and Kelleher SL. 2010 X-ray fluorescence microscopy reveals accumulation and secretion of intracellular zinc pools in the lactating mammary gland. PLoS One, 5:e11078.

Seo YA and Kelleher SL. 2010 Functional analysis of two single nucleotide polymorphisms in SLC30A2 (ZnT2): Implications for mammary gland function and breast disease in women. Physiol Genomics, 42A: 219-227.

Lopez V, Kelleher SL. 2010 Zip6 attenuation promotes epithelial-to-mesenchymal transition in ductal breast tumor (T47D) cells. Exp Cell Res, 316:366-375.

Qian L, Lopez V, Seo YA, Kelleher SL. Prolactin regulates ZnT2 expression through the JAK2/STAT5 signaling pathway in mammary cells. Am J Physiol Cell Physiol. 2009 297:C369-77.

Lopez V, Kelleher SL. Zinc transporter-2 (ZnT2) variants are localized to distinct sub-cellular compartments and functionally transport zinc. Biochem J 2009 422(1):43-52.

Kelleher SL, Lopez V, Lonnerdal BL, Dufner-Beattie J, Andrews GK. 2009 Zip3 (Slc39a3) functions in zinc reuptake from the alveolar lumen in lactating mammary gland. Am J Physiol Regul Integr Comp Physiol. 91:R194-201.

Chowanadisai W, Lönnerdal B, Kelleher SL. Identification of a mutation in SLC30A2 (ZnT-2) in women with low milk zinc concentration that results in transient neonatal zinc deficiency. J Biol Chem 2006, 281(51):39699-707.

Courses Taught

NUTRN 551 Nutrition and Reproductive Function

NUTRN 551 Concepts in Mineral Metabolism

NUTRN 511 Maternal and Infant Nutrition

NUTR 446 Nutrient Metabolism II

Strategic Themes

  • Domains of Health and Behavior